We recommend taking Cheers after anytime you consume alcohol, no matter the amount or time of day. There are no known side-effects of Cheers. We have had an expert toxicologist review the safety of Cheers for one of our fundraising rounds due diligence requests and came back with overly positive results and with no concerns! Even if a person only consumes one drink, they will still experience the negative effects of alcohol, and Cheers Restore is designed to reduce those negative effects!